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10.1093/hmg/ddu328 12 GhumanS.Van HemelrijckM.GarmoH.HolmbergL.MalmstrmH.LambeM.et al (2017)

S7), demonstrating pathway-appropriate modulation: semaglutide downregulated GLP-1 expression, roflumilast, imatinib, navitoclax and bestatin, respectively decreased PDE-4, PDGFR/, BCL2, and CD13, while palacaparib increased PARP-1 cleavage, consistent with its role in inducing apoptosis

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To determine if the increased activity of glutathione synthetase in resistant plants was due to increased gene expression, qPCR was carried out to determine the abundance of transcripts of genes encoding glutathione synthetases

Thus, these results suggest that liraglutide could reduce, at least in part, the secretion of pro-inflammatory cytokines in OA synovium by stimulating macrophages and polarization toward an M2 anti-inflammatory phenotype, leading to a decrease in OA-induced joint destruction