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The first 48 hours favor cold (to limit initial inflammation), and the period after 48 hours favors warmth (to promote resolution)
Semaglutide Is the Better-Evidenced Agent Several randomized trials conducted between 2021 and 2025 showed semaglutide 1.02.4mg weekly produces roughly 1015% weight loss in PCOS patients over 612 months, with parallel improvements in menstrual cycle frequency, testosterone, sex hormone-binding globulin (SHBG), and HOMA-IR (a marker of insulin resistance)
Tia's Perimenopause/Menopause Assessment is the best place to start
Eli Lilly, the maker of tirzepatide, recently published results of a head-to-head trial comparing weight loss of Zepbound (tirzepatide) and Wegovy (semaglutide)
Among these, dysglycemia is an important predisposing factor: studies have shown that chronic inhibition of cerebral energy metabolism, especially reduced glucose utilization, can induce epileptic seizures (17), while decreasing glycogenolysis and increasing glucose utilization and metabolism via the TCA cycle exerts an antiseizure effect (19)
(2023) Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial
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