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End of study sample collection At the end of the study, at experimental day 140, an aliquot of 25 g of excreta sample was collected from each cage and freeze-dried (James Hutton Institute, Aberdeen, UK)

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Sensitivity analyses were conducted after removing the RCT with high-risk of bias and 3 non-RCTs with serious and critical risk of bias

Furthermore, like most transcription factors, direct targeting of NRF2 itself has been extremely challenging

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