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Gradually increasing fiber intake through fruits, vegetables, and whole grains can help, though this should be done slowly to avoid worsening bloating

However, downgrading applies due to the post hoc nature of renal endpoints and lack of adjustment for multiplicity

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Furthermore, oxidative stress can enhance the expression of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix and facilitate tumor invasion and metastasis [116]