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With increasing concern over adverse events across the class, liver safety, cardiovascular outcomes, PK and PD stability, and dose optimized adherence will decide which assets rise to best in class status

References & Further Reading How the spinach, Popeye, and iron decimal point error myth was finally bust M Sutton The effect of organic acids, phytates and polyphenols on the absorption of iron from vegetables M Gillooly and others Iron deficiency N S Scrimshaw Oxalic acid does not influence non-haem iron absorption in humans S Storcksdieck and others Mineral composition of boiled, green leafy vegetables found in Hawaii and iron bioavailability using the in vitro digestion method A Perfecto Iron absorption and phenolic compounds: importance of different phenolic structures M Brune and others

Sig Transduct Target Ther 11 , 307 (2026)

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