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We therefore employed two different assays to test whether Prx1 in the mitochondrial matrix can be hyperoxidized at the concentrations of H 2 O 2 used in our acute stress assays

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In 2014, the GLS inhibitor CB-839, undergoing clinical trials, was reported to possess potent anti-tumor activity, offering a novel avenue for targeted cancer therapy through modulation of glutamine metabolism [14]

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