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The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo

BMJ: Br Med J

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Because it works through the natural GHRH receptor, growth-hormone output stays under the bodys own feedback control a key contrast with exogenous GH

DPP-4i could reduce renal tubular damage associated with DKD by improving mitochondrial homeostasis via the stromal cell-derived factor 1/C-X-C chemokine receptor type 4 pathway