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10.1016/j.jphs.2020.03.005 161 YazdiA.ShirmohammadiK.ParvanehE.Entezari-MalekiT.HosseiniS
Metallomics 10:17431754
It has remarkable regenerative properties, particularly for gut lining repair, tendon and ligament healing, joint inflammation and neuroprotection
While sometimes this is necessary to prevent discomfort and/or mastitis, be cautious not to inadvertently encourage increased production
Notably, inhibition of MAPK/ERK signalling exacerbates 3-HK-induced mitochondrial dysfunction and cell death, implicating impaired cellular resilience pathways in amplifying KYN-mediated toxicity
Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ (2022) Nat Rev Cancer 22:102113
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