The meniscus is made of a dense extracellular matrix (collagen fibers + proteoglycans)
Acknowledgements Thank you to Theresa Daily for proofreading the English manuscript
Bioactive peptides short amino acid sequences capable of modulating cellular behaviour have been shown in numerous in vitro studies to influence fibroblast activity, keratinocyte migration, and the synthesis of key extracellular matrix components including collagen types I and III, elastin, and glycosaminoglycans
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Structural optimization revealed that incorporating small hydrophobic groups, such as cyclopropylmethyl, at the N 7 -position enhanced potency, while a sulfonyl group at the N 2 -position and (4-fluorophenyl) amino at the C 3 -position improved metabolic stability (Figures 7A,B)