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Sinha et al

The proximal tubular cells account for the majority of kidney NO synthesis [189, 190], thus kidney damage and atrophy, a primary corollary of CKD, results in decreased synthesis of L-arginine

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It is synthesized in every cell from the amino acids glutamate, cysteine, and glycine (Lu, Biochimica et Biophysica Acta , 2013)

Notably, there were no significant fluctuations in body weight for all treatment groups during the treatment course (Fig

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