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This increases the risk of liver damage when using acetaminophen along with chronic alcohol consumption adding to the damage to the liver from alcohol.[ref] Glutathione System Overwhelmed : Under normal circumstances, NAPQI is quickly neutralized by conjugation with glutathione, a powerful antioxidan t found in liver cells, and then excreted from the body

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Only molecules of less than 800 dalton (Da) are small enough to pass through TJs paracellularly (Obermeier et al., 2013)