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PMID: 40250899, PMCID: PMC12046986, DOI: 10.1016/j.jaccas.2025.103416
For women over 40 who are already losing muscle naturally (sarcopenia), this is a disaster
In summary, the pronounced disparity in DEG counts between semaglutide and tirzepatide is best understood as the outcome of a multifactorial interplay involving (i) distinct pharmacological mechanisms and receptor selectivity, (ii) non-equivalent dosing and consequent differences in transcriptomic breadth, and (iii) biological as well as technical variability, rather than a straightforward difference in therapeutic potency
Names like Ozempic and Mounjaro are everywhere
The following overview is based on publicly available disclosures
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