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Glutathione peroxidase 4 (GPX4) utilizes GSH to convert lipid hydroperoxides into nontoxic lipid alcohols, thereby preventing ferroptosis [19]

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J Exp Med (1996) 184:9639

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Comparison of these directly determined rate constants with those predicted by fitting c and G 0 using four elevated temperature simulations ( T = 440 K, 460 K, 480 K, & 500 K) shows excellent overall agreement for all four solutes over the entire temperature range, directly validating our method (Fig