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In a study with 28 days of exendin-4 treatment in mice with diet-induced obesity, the initial transient reduction in food intake disappeared over time [23]
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doi: 10.1001/jamanetworkopen.2020.25850 68
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doi: 10.1210/en.2010-0068 194 ToniN.TengE
Systems such as dual oxide antigen-captured nanosponges, self-cascade penetrating nanoflakes, and nanosponge-mediated dendritic cell modulation have demonstrated how structural optimization within complex immune microenvironments can achieve precise targeting and enhanced immunoregulatory activity [71,72,73,74]
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