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Dual agonism may provide greater consistency of response across diverse patient populations by targeting multiple mechanisms simultaneously
its use outside of clinical trials in the UK is therefore unlicensed
Contraindications: Uncontrolled asthma Known hypersensitivity to pilocarpine When miosis is undesirable Side Effects: The most frequent adverse experiences are a consequence of the expected pharmacologic effects of pilocarpine & include headache, sweating, flushing, increased urinary frequency
Compounds such as melatonin, N-acetylcysteine, vitamin C, and selenium have demonstrated protective effects in preclinical and some clinical studies by enhancing mitochondrial integrity and reducing systemic inflammation (Mantzarlis et al., 2017
Stimulation of melanocytes by an MC1R agonist could theoretically promote progression of pre-existing melanocytic lesions to malignant melanoma
