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Limitations of Current Human Data It's important to be transparent about what the human research does and doesn't show: Large-scale, long-term randomized controlled trials for body composition, anti-aging, and performance applications haven't been published
The pentose phosphate pathway can also function as an anabolic pathway that utilizes the six carbons of glucose to generate five carbon sugars, particularly ribose-5-phosphate (R5P) that is required for purine and pyrimidine nucleotide biosynthesis
One meta-analysis and systemic review of 26 trials published in April 2025 in JAMA Neurology suggested that they could help lower dementia risk
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10.1196/annals.1320.005
