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We do not know if the body needs a constant supply of the peptide to heal, or if a quick pulse is enough to trigger a self-sustaining healing process

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This presents a meaningful clinical concern, particularly in populations exposed to polypharmacy or managing complex comorbidities

(PMID 23755725) Sikiri P, Seiwerth S, Brcic L, et al

In my studies of patients using methylene blue oral rinse, about 5% of patients reported a burning sensation the first time they used the solution