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On the other hand, the experiment was conducted in accordance with the ARRIVE (Animal Research: Reporting of in Vivo Experiments) guidelines [63] for the care and use of research animals Consent for publication NA Competing interests The authors declare that they have no conflict of interest
Safety assessments were conducted from baseline through end-of-study follow-up, and pharmacokinetic and exploratory assessments were performed at prespecified time points, including serial sampling up to 672 h after the final dose
FDA-approved medications for these conditions have been scarce
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