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RNAi therapeutics: principles, prospects and challenges

Purity is a critical variable: a semaglutide sample at 92% purity introduces approximately 8% unknown impurities that may interact non-specifically with receptors or downstream signaling enzymes, confounding dose-response curves and compromising data reproducibility across experimental runs

EBioMedicine 86, 104382

In particular, there is some evidence that eryptotic cells might undergo swelling, which is much less common [89]

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