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Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia

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Maarbjerg and Jeanett Borregaard were employees of Novo Nordisk A/S at the time of conduct of the trial and preparation of this manuscript and are shareholders of Novo Nordisk A/S (current affiliation of SJM: Zealand Pharma A/S, Sborg, Denmark

In much of the modern world, in which the population is now exposed to widely available and vastly excessive calories as well as to increasingly sedentary lifestyles 56,57,58,59 , these ancient survival-ensuring mechanisms are not merely irrelevant, but actually counter-productive and contribute to the obesity epidemic