Glutathione is also involved in metabolizing insulin and regulating blood glucose levels
Important discoveries highlight the functions of important genes identified by gene ontology and pathway enrichment studies linked to p53 signaling, mitophagy, and protein degradation pathways, such as Tumor protein p53 (TP53) , Enhancer of Zeste Homolog 2 (EZH2 ), Tissue inhibitor matrix metalloproteinase 1 (TIMP1) , Solute carrier family 3 member 2 (SLC3A2), and Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) (Zeng et al., 2025)
Rachele explains that Glutathione can also be used proactively: Some people use it as a preventive tool, especially before a big physical challenge, because they know it can help keep inflammation as low as possible before the body goes through that stress. How to Increase Glutathione Levels Your body naturally makes Glutathione, but certain habits can help maintain optimal levels
Start with one compound (typically Tirzepatide), titrate to your target dose, and stabilize before adding GHK-Cu
Always use a broad-spectrum SPF during the daythis isn't negotiable when using any brightening products
Side Effects and the Copper Uglies Explained GHK-Cu has a strong safety profile in topical research, but a small subset of users experience a transient phase known as the copper uglies. A 2023 clinical safety review covering 12 studies and 512 participants reported that the most common side effects of topical GHK-Cu were transient and mild