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By staying in the middle zone and targeting the outer surface, you minimize the chance of encountering significant blood vessels

8.7 Hepatic Impairment No dosage adjustment of ZEPBOUND is recommended for patients with hepatic impairment

You are injecting a liquid thats going to disperse into the muscle and sit there for a while, so there may be a little bit of soreness related to that. Other common side effects include diarrhea, headache, and swelling (and not only at the site of the injection)

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PubMed searches return zero combined trials as of early 2026

Stojanovska, L.G