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considerable interest exists in identifying these glucose-independent renoprotective actions Data from clinical trials suggest that GLP-1R agonists and, to a lesser extent, DPP-4 inhibitors marginally improve surrogate renal end points, plausibly beyond the effects of improved glycaemic control Abstract The gastrointestinal tract the largest endocrine network in human physiology orchestrates signals from the external environment to maintain neural and hormonal control of homeostasis

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10.1016/j.mito.2016.06.007 124 YuberoD.O'callaghanM.MonteroR.OrmazabalA.ArmstrongJ.EspinosC.et al

These are independent treatment pathways, and changes should only be made by a licensed healthcare provider based on blood test results