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Center for epidemiologic studies depression scale (CES-D) as a screening instrument for depression among community-residing older adults
In both monotherapy studies, patients currently on an antihyperglycemic agent discontinued the agent, and underwent a diet, exercise, and drug wash-out period of about 7 weeks
In PIONEER 4, oral semaglutide 14 mg once daily was compared with both liraglutide 1.8 mg and placebo in patients receiving metformin with or without a sodium-glucose cotransporter-2 inhibitor (SGLT2i) [8]
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GLP-1 RAs are drugs that imitate the function of natural GLP-1, a hormone in the intestine that controls glucose metabolism and feelings of fullness
At the bottom of the orthosteric pocket, the side chain of R310 6.40b pointed to the TMD core and formed a cation-pi stacking with Y241 3.44b , where it pointed to ECL3 and made no contact with TMD core in the GLP-1 bound structure
doi:10.2337/dc21-S006 ADA
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