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In a study published in NEJM SURMOUNT 5*, an international comparative open-label, controlled trial, adult participants with obesity but without type 2 diabetes the 2 agents were compared in maximally tolerated recommended doses

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Incretin-based therapies were not associated with an increased or decreased incidence of depression or self-harm compared with sulfonylureas

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doi: 10.1038/s41574-018-0016-2 32 Eli Lilly and Company

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