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Statements Author contributions JC: Writing original draft

doi:10.3390/ijms231710136 [Made by author on BioRender] These pathologies, on top of being associated with a degradation of how the Blood-Brain Barrier work, all involve altered processes in the brain implied in the development of the disease

IGF-1 Uses Some of the reasons why Insulin-like Growth Factor 1 is a big deal, or its advantages include: IGF-1 is used as a diagnostic test, where low levels depict growth hormone deficiency and high levels depict acromegaly

First, it upregulates growth hormone receptor expression at the tendon-to-bone junction, making tissue more responsive to endogenous growth signals

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