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Fibrogenesis is known to progress into myocardial impairment leading to DCM through the SMAD -dependent pathways and independent pathways such as the non-canonical MAPK

(28) The crude incidence rates of LLA were 6.1 per 10,000 person-years for GLP-1 receptor agonists, 1.5 for SGLT-2 inhibitors, 4.6 for DPP-4 inhibitors, and 1.9 for older agents

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These advances underscore the translational value of microbiome research in the precision medicine of mental disorders