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In fact, 83.5% of the patients who developed complications at the end of the study already had DR at baseline, and the level was not described in the paper

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It is possible that the latter group might find a reduction in the efficacy of their HRT when using tirzepatide (for the same pharmacokinetic reasons discussed regarding contraception), but the likelihood and magnitude of this is unknown

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Neurotrophic peptides (Semax, Cerebrolysin) that create the biological conditions for repair could follow once the acute danger has passed