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First identified in human plasma, its concentration declines significantly with agefrom approximately 200 ng/mL in youth to 80 ng/mL by the age of 60 (Pickart and Margolina 2018)

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Claims submitted with J0610 for dates of service on or after April 1, 2023 are rejected by Medicare and most Medicaid programs

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Diagnosis is supported based on vitamin B 12 blood levels below 150180 pmol/L (200250 pg/mL) in adults