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Insights into energy balance from doubly labeled water
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Inhibition of GLP-1 action resulted in a quicker gastric emptying rate and a robust glycemic effect confirmation of its action in regulating blood glucose
However, the full glycaemic benefitreflected in HbA1c reductiontakes approximately 1216 weeks to manifest, as HbA1c represents average blood glucose over the preceding 23 months
This pharmacologic gastroparesis can unpredictably delay absorption of other orally administered drugs, potentially altering expected toxicokinetics
doi: 10.1128/cmr.00134-14 348 Colomb-CotinatMLacosteJBrun-BuissonCJarlierVCoignardBVauxS
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