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In the hospital settings, the implementation of GLP-1RAs may be particularly challenging, especially with once-weekly formulations, due to the potential need for discontinuation before surgical or diagnostic procedures or in the event of clinical deterioration
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Recent studies using tissue/cell-specific gene knockout mouse models and cell culture techniques have clearly demonstrated that locally produced IGF-I is more critical than the systemic IGF-I in supporting embryonic and postnatal skeletal development and bone remodeling
It is also used to diminish the visibility of age spots, sun spots, and other forms of skin discoloration
Additionally, lixisenatide was associated with fewer gastrointestinal symptoms compared to exenatide, while long-acting GLP-1RAs generally caused less nausea and vomiting but more diarrhea than short-acting agents (49)
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