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The FDA announced the action on April 15, 2026 (Federal Register notice April 16), and the peptides come off the Category 2 list effective April 23, 2026

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Glycine variants of both peptides cost more because the alternate buffer system requires more complex compounding

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Summary: B12 and lipo shots combine vitamin B12 injections with lipotropic compounds, but only B12 injections are licensed NHS medicines for treating confirmed deficiency, whilst lipotropic injections lack MHRA approval and clinical evidence

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These therapies are prescribed only after a thorough medical evaluation and discussion of potential risks, benefits, and alternatives

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