doi:10.1007/BF00581575 Graf MV, Kastin AJ
reported a significant reduction (SMD 0.36 kg), though this effect also weakened after one year [13]
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A personalized approach considers: Your BMI and weight loss goals Blood sugar response Side effects (especially nausea and GI symptoms) Coexisting health conditions like PCOS or hypothyroidism Whether you're using it for diabetes, obesity, or both Doctors usually start you on the lowest dose, then increase it every few weeks if tolerated
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Oral administration of GSH is not very effective, however, because it is poorly absorbed through digestion and insufficient amounts cross the blood-brain barrier