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Without documentation, gradual changes often go unnoticed, and the lack of perceived progress can lead to premature discontinuation
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This would be dramatically more effective than the one-size-fits-all approach that current products, including Pendulum, use
Outcomes would be measured with validated instruments: instrumental elasticity and firmness, corneometry and cutometry, standardized photography with blinded grading, and, most convincingly, dermal biopsies quantifying collagen density and organization before and after
Active and passive facial measures quantify changes in expressive behaviors such as facial expressions, blinking, and gaze shifts, indicating subtle phenotypic features such as masked face, reduced emotional expression, and visuogait coordination [154, 191, 192]
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