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Its clinical development for obesity was discontinued in 2007 after the pivotal 536-participant Phase IIb trial failed to meet its primary efficacy endpoint, and no formulation of the compound has received FDA approval since

This strategy allows companies to innovate on the foundations of existing blockbusters like semaglutide and tirzepatide

You may be able to maintain muscle, or in some cases slowly build it, if your protein intake is high and your training is consistent, but its not a muscle-building compound

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Rushing through meals increases the volume of food entering your stomach at once, overwhelming your slowed digestive capacity and triggering nausea