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Germ cells adjacent to the DTC are in a region called the progenitor zone, which distally contains stem cells, then cells completing a terminal mitotic cell cycle and cells undergoing meiotic S-phase, followed proximally by cells undergoing the earliest stages of meiotic prophase, leptotene and zygotene [4,6,7] ( Fig 1 )

That shift is physiologic

Reactive oxygen species (ROS) production in DV2-infected HepG2 cells with antioxidant or buthionine sulfoximine (BSO) administration