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The Clinical Data: Everything Published So Far Phase 1 First-in-Human (Oral Formulation) Published: The Lancet, June 2025 Participants: 144 adults with overweight or obesity (BMI 25.039.9), no diabetes Duration: Up to 12 weeks Dosing: Once-daily oral amycretin, up to 2 50 mg Results: - 50 mg dose: 10.4% mean body weight change - 2 50 mg dose: 13.1% mean body weight change - Placebo: 1.2% 13% weight loss in 12 weeks
They include: Irritability Jitters Poor feeding habits Breathing difficulties Premature birth Increased risk of stillbirth Increased risk of spontaneous abortion Taking antidepressants during the third trimester of pregnancy may also increase the risk of things such as lower Apgar scores (a scoring system that checks the health of the infant within minutes of birth), restlessness, low blood sugar, vomiting, temperature instability, nervousness, and tremor
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See the Tirzepatide protocol page for the standalone reference
There was no blinding, there was no control group, and there were no validated questionnaires
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