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Methods 19, 2428

In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy

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Redox regulation of gamma-glutamyl transpeptidase

These new discoveries, together with the in-depth preclinical characterization of NAD + modulators and ongoing developments in their translation in humans, will open further avenues of study of this essential cofactor and its clinical therapeutic potential

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