In a single piece, he concisely captures: the state of the field the most important clinical trials where the pipeline is headed These Clinical trials are raising the bar and expanding future treatment options: Retatrutide ~24% weight loss (triple agonist) MariTide 1216% weight loss (GLP-1 + GIP antagonist) CagriSema up to 20% weight loss + ~2% HbA1c drop Orforglipron oral GLP-1, HbA1c 1.5%, weight 7.6% IcoSema weekly semaglutide + once-weekly insulin Even more exciting
All medical content on this blog is created based on reputable, evidence-based sources and reviewed regularly for accuracy and relevance
Wake H, Takahashi Y, Yoshii Y et al (2020) Histidine-rich glycoprotein possesses antioxidant activity through self-oxidation and inhibition of hydroxyl radical production via chelating divalent metal ions in Fentons reaction
Here are some tips to help you reach your goals: Follow a Healthy Diet Focus on nutrient-rich foods that provide the essential nutrients your body needs
doi: 10.3389/fmolb.2026.1755542 Received 27 November 2025 Revised 15 January 2026 Accepted 22 January 2026 Published 16 February 2026 Volume 13 - 2026 Edited by Joana Pinto, University of Porto, Portugal Reviewed by Gloria Riitano, Sapienza University of Rome, Italy Jing Li, University of Colorado Anschutz Medical Campus, United States Updates Copyright 2026 Masood, Almalki, Malkawi, Al Mogren, Jaafar, Benabdelkamel, Alfadda, Fallata, Alarfaj, Siaj and Abdel Rahman
Any laboratory animal work must be approved and carried out under the relevant institutional animal-care rules