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Co-investigator Ummi Ammarah, PhD candidate, Laboratory of Tumor Inflammation and Angiogenesis, VIB-KU Leuven, Leuven, Belgium, and Molecular Biotechnology Center, University of Turin, Turin, Italy, concludes, Our results provide the first proof-of-concept that metabolic drugs can be effectively used to treat muscular dystrophies, offering a novel strategy by bypassing the genetic defect and modifying a non-musclerelated function. Joran Lauwers Notes for editors The article is Pharmacologic Inhibition of Glutamate Dehydrogenase 1 Improves Functional Recovery of Neuromuscular Junctions and Muscle Function in Duchenne Muscular Dystrophy, by Andreia Pereira-Nunes, Ummi Ammarah, Min Shang, Iris Charatsidou, Himal Sharma, Bruna Pereira Sorroche, Max Nobis, Thibaut Burg, Stijn Verschoren, Frdric Relaix, Alessio Rotini, Ludo Van Den Bosch, Marcello Delfini, Emanuele Berardi, and Massimiliano Mazzone ( It appears online ahead of The American Journal of Pathology , volume 195, issue 8 (August 2025), published by Elsevier

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Compared to the existing IBP4/SHBG ratio test, previously developed using mass spectrometry [19], our three-protein panel achieved higher accuracy across all validation cohorts and gestational windows