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1997 Sexual Function Arousal Pathway Models Preclinical research using MTII as a non-selective MC agonist probe contributed to the discovery of melanocortin-mediated arousal pathways, eventually leading to the development of PT-141 (bremelanotide) as a more selective MC4R-focused compound
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In SURMOUNT-1, 2,539 adults with obesity, or with overweight and at least one weight-related complication, excluding diabetes, were randomized to once-weekly tirzepatide at 5 mg, 10 mg or 15 mg or to placebo for 72 weeks including a 20-week escalation period
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