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Avoiding fatty, greasy, or heavily spiced foods during the initial titration period reduces gastrointestinal irritation

GLP-1 receptor agonists like semaglutide work best when dosed consistently, and the standard approach involves a single weekly injection that increases gradually over time

Doctors have observed that along with fat loss, a small portion of weight lost on GLP-1 RAs can be fat-free mass (mostly muscle)

doi: 10.1038/nrdp.2015.56 47 MeadowsJ

That said, collaboration is wise: communicate with the patients PCP, dont usurp necessary medical workups (rule out endocrine causes, get baseline labs), and refer to specialists (endocrinology, cardiology) when appropriate