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2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

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Future work will use longitudinal profiling and single-cell sequencing to assess cell-type-specific GSH roles 5 Conclusion In conclusion, by leveraging multi-omics integration, the present study identified GSH metabolism as a pivotal node in SAE, while providing a comprehensive molecular framework for SAE pathogenesis, and linking microglia-driven neuroinflammation to hippocampal oxidative damage

Those with severe kidney or liver disease, pregnancy or breastfeeding, or a history of lactic acidosis

In part, these medications work by sending signals to the brain to decrease appetite and by slowing digestion, which helps people feel fuller for longer

Phase 3 results are expected from 2026 onward, with potential FDA approval in the 20262027 window if the trial data supports it