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However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics
However, achieving optimal results with tirzepatide requires consistent tracking, proper dosing schedules, and careful monitoring of side effects and progress
Therefore, we believe Novo will not be able to avail these benefits retrospectively for semaglutides product patent
Notably, SGLT2i have also been shown to be effective for the treatment of patients with HFmrEF and HFpEF, with their efficacy independent of ejection fraction
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