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Heres how coffee enemas are thought to benefit the liver: Bile Duct Stimulation : Coffee, when administered rectally, is absorbed through the walls of the colon and stimulates the liver to produce bile, which is a natural detoxifier

10.1016/j.cell.2013.10.041 129 SuK

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Peptides that affect glucose and insulin signaling can aggravate dysglycemia or hide insulin requirements