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169 First-generation agents, including verapamil and cyclosporin A, showed in vitro efficacy but were hampered by off-target toxicity and limited clinical applicability

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If GLP-1 is detectable in synovial fluid, that supports the biological plausibility that GLP-1-based therapies could potentially act directly in the joint as well as systemically. Tue Wenzel Kragstrup, MD, PhD After comparing participants blood and joint fluid samples to those from healthy volunteers, researchers detected small amounts of the bodys natural GLP-1 hormone in joint fluid

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