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Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, et al

Glucagon-like peptide-1-(736)amide is transformed to glucagon-like peptide-1-(936)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine

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Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)

the active site sequence motif and the residues immediately before the cis -Pro and before the serine involved in GSH binding