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Tier 2 (Moderate risk): 3x to 5x the prescribed dose, or any dose in a patient with a cardiovascular or hepatic comorbidity

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Subsequently, for these data as well as the alpha diversity analyses, each treatment group (within each phylum or genus for the relative abundance data) was analyzed for normal distribution (ShapiroWilk test) and the data across groups were tested for homoscedasticity (BrownForsythe test)