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As a potent antioxidant, it inhibits the enzyme tyrosinase, thereby reducing melanin production and promoting skin lightening and brightening

If tolerated, increase to 7 mg daily

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The same promising effects on MACE were shown in the absence of DM, in patients with heart failure and obesity (SELECT trial, Lincoff et al, NEJM 2023, Deanfield et al, Lancet 2024)