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For example, in the STEP-1 clinical trial, participants taking semaglutide lost an average of 11.6 pounds of lean body mass compared to just 4 pounds in the placebo group
If truly non-responsive to GLP-1 therapy, non-GLP-1 alternatives like phentermine-topiramate or the upcoming amylin-based therapies work through different mechanisms that may be more effective for your specific biology
Retatrutide does not cause fatigue through a single mechanism
Have you tried endurance activities such as CrossFit, cycling, running, or swimming? Or maybe youve been on a diet for a long time and havent noticed any results? Then you know youve reached a point where nothing seems to be able to keep you going
Interestingly, tirzepatide, a dual-acting GIP/GLP-1 receptor agonist that is now clinically approved for both obesity and T2D, was designed with an amino acid sequence closely resembling that of native GIP, resulting in strong preference for GIPR binding over the GLP-1R
But then I was like, I should just stand on these
